Aminoglycosideinduced nephrotoxicity in children pdf. Drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare utilization. Low multiples of human therapeutic doses to animals e. Aminoglycosideinduced renal phospholipidosis and nephrotoxicity. Effect of high dietary cholesterol on gentamicininduced. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Study was conducted in the department of histopathology with the collaboration of the department of. Gentamicin sulfate equivalent to 40 mg gentamicin, methylparaben 1. Sildenafil, a selective phosphodiesterase5 inhibitor, was reported to prevent or decrease tissue injury. Comparative study on gentamicin and streptomycin induced. Structural latency of lysosomal nacetyl3glucosaminidasefollowing gentamicin treatment mean of four independent experiments sem.
Author links open overlay panel pitchai balakumar a ankur rohilla b arunachalam thangathirupathi a. Saeed mehrzadi, a seyed kamran kamrava, b banafshe dormanesh, c manijeh motevalian, a azam hosseinzadeh, a seyed mohammad taghi hosseini tabatabaei, d habib ghaznavi e. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Protective effect of transresveratrol on gentamicin. Aminoglycoside antibiotics, in particular gentamicin and tobramycin, are still commonly used in paediatric clinical practice. Dailymed gentamicin gentamicin sulfate injection, solution. However, treatment with gentamicin is considered to be limited as it induces an oxidative stress. Ethanolic extract of garlic for attenuation of gentamicin. The effects of cisplatininduced nephrotoxicity on the pharmacokinetics of a renally excreted antibiotic, gentamicin, were studied in f344 rats. Esterhai jl, bednar j, kimmelman cp gentamicininduced ototoxicity complicating treatment of chronic osteomyelitis. Gentamicininduced nephrotoxicity results in necrosis of proximal tubular epithelial cells.
Gentamicininduced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the. Nephrotoxic effects of aminoglycosides on the developing. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. Recent epidemiological studies, using more widely accepted. Pdf gentamicin induced nephrotoxicity in albino mice. Clinicians are well aware that rising serum creatinine levels in patients treated with gentamicin could indicate nephrotoxicity. Although several in vitro and in vivo approaches have been proposed to reduce vaninduced renal toxicity, such as antioxidants or erythropoietin 1, 7, 11, 14, it is unclear whether such approaches would. Gentamicin injection is a sterile, nonpyrogenic aqueous solution for parenteral administration. Aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. Prevention of vaninduced nephrotoxicity without decreasing efficacy is a highly desirable objective in treatment of mrsainduced crbsi. However, many do not know that, contrary to textbooks and antibiotic guidelines, gentamicin ototoxicity causes impairment of vestibular.
One of the complications of gentamicin and streptomycin is nephrotoxicity. These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of abuse such as cocaine. The free radicals release from the renal tubules cell mitochondria was the main factor in the gentamicin induced nephrotoxicity 22,23. Gentamicin gm induced nephrotoxicity may be sex hormones related. Combinational effect of curcumin and metformin against. Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at 3 mgkg moderate to marked kidney damage, two thirds of. Fish were given a single intraperitoneal injection of 50 mgkg gentamicin and sacrificed at 1, 4, 14, and 21 days. Nephrotoxicity is a serious side effect of gentamicin and is believed to be related to reactive oxygen species in the kidney. Rapamycin protects against gentamicininduced acute kidney. Effect of carnosine on gentamicininduced nephrotoxicity. Nephrotoxicity due to a aminoglycosides b cyclophosphamide c cisplatin d radiocontrast e analgesic f.
This article is from iranian journal of basic medical sciences, volume 16. Pdf protective effect of chelerythrine on gentamicin. Our current knowledge of drug induced kidney disease is limited due to varying definitions of kidney injury, incomplete assessment of concurrent risk factors and lack of long term outcome reporting. Gentamicin gm is an antibiotic related to aminoglycoside group that is used in treating gram. We examined this repair process in the freshwater goldfish, carassius auratus. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. Protective effect of apocynin against gentamicininduced. Protective effect of chelerythrine on gentamicininduced nephrotoxicity article pdf available in cell biochemistry and function 241. Melatonin synergistically enhances protective effect of atorvastatin against gentamicininduced nephrotoxicity in rat kidney. Gentamicin and streptomycin are the most common antibiotics in group of aminoglycosides. These drugs cause nephrotoxicity, which particularly affects the proximal tubule epithelial cells due to selective endocytosis and accumulation of aminoglycosides via the multiligand receptor megalin. Effect of normobaric hyperoxia on gentamicininduced.
In mammals, the injured nephron can be repaired by migration and division of surviving cells. Aminoglycoside nephrotoxicity kidney international. The 6rs of drug induced nephrotoxicity bmc nephrology. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Effect of normobaric hyperoxia on gentamicininduced nephrotoxicity in rats. Aminoglycosides cause a simultaneous inhibition of variety. Although a clear recognition of the patient and treatmentrelated risk factors, combined with the onceaday schedule and effective monitoring procedures, have definitely improved the situation over what prevailed in the early 1980s, we are still short of having brought the safety of. Risk of aki with gentamicin as surgical prophylaxis. Aminoglycoside antibiotics, such as gentamicin, can produce nephrotoxicity in dogs, due to in part to an imbalance of pro. However, its usefulness is limited by its nephrotoxicity. Plajer sm, chin pk, vellabrincat jw, buffery pj, begg ej. Nephrotoxic effects of aminoglycosides on the developing kidney samira samieezafarghandy1. Gentamicin gnt is an aminoglycoside antibiotic used for the treatment of serious grampositive and gramnegative bacterial infections.
Aminoglycosideinduced nephrotoxicity indiana university. Protective effect of montelukast which is cysteinylleukotriene receptor antagonist on gentamicininduced nephrotoxicity and oxidative damage in rat kidney. The cessation of the treatment allows a recovery to control values within approximately 8 days. The pathogenesis of gentamicin nephrotoxicity is unclear. Although the rates of aki we observed are similar to other reported rates of gentamicin nephrotoxicity, 1,2,5,1012 it is clear that these rates are higher than in some studies, which in part may be due to differing definitions of nephrotoxicity. Autophagy is a highly conserved physiological process involved in removing damaged or aged. To evaluate histopathological changes of gentamicin induced nephrotoxicity in rabbits receiving the combination of ciprofloxacin and gentamicin compared with rabbits receiving gentamicin alone. Sildenafil ameliorates gentamicininduced nephrotoxicity.
Administration of gentamicin to rabbits intramuscularly at a dose of 80 mgkg per day for 5 days induced nephrotoxicity exhibited by significantly p g entamicin is an important bactericidal antibiotic with two serious potential adverse effects. However, due to its side effects, there are some limitations in the use of gentamicin and streptomycin. Until these interventions become adopted in clinical practice, however, clinicians must utilize established strategies to reduce the incidence of aminoglycosideinduced nephrotoxicity. Influence of iron, deferoxamine and ascorbic acid on gentamicininduced nephrotoxicity in rats. A number of crude herbal extracts have been reported to ameliorate gentamicininduced nephrotoxicity. Gentamicininduced nephrotoxicity 585 gentamicin for 8 days, mgkg fig. The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gminduced nephrotoxicity in male rats. Abstract objective to evaluate nephroprotective potential of solanum xanthocarpum s. Do we have a promising therapeutic approach to blunt it. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated.
Ethanolic extract of garlic for attenuation of gentamicininduced nephrotoxicity in wistar rats hamid nasri,1 mehdi nematbakhsh,1 mahmoud rafieiankopaei2 introduction. Nephroprotective activity of solanum xanthocarpum fruit. The aim of this work has been to study whether tr has a protective effect on gentamicininduced nephrotoxicity in vivo and the effect of tr on lipid. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. Gentamicin nephrotoxicity is one of the common causes of drug induced aki in hospitalized patients. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicinadministered rats. Cisplatin caused a significant decrease in gentamicin clearance. A single dose of gentamicin 30 mgkg, iv was given to different groups of rats alone, at the same time as, or on day 4, 7, 15, or 29 following cisplatin administration 6 mgkg, iv. Finally, determination of a patients or donors genotype of drugmetabolizing genes or of mol. Methods twentyfour wistar rats were divided into four groups n6.
Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Electronic surveillance presents a powerful tool to identify susceptible. Does propylthiouracil increase the gentamicininduced. Nephrotoxicity can be defined as the adverse effect of substances on renal function perazella, 2009. Development of new nephrons in adult kidneys following. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicininduced nephrotoxicity in rats. Effects of cisplatininduced nephrotoxicity on gentamicin. Aminoglycosides have long been one of the commonest causes of druginduced nephrotoxicity. Risk factors and comparisons of clinical nephrotoxicity of aminoglycosides.
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